Phenylephrine is an alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction.
- Mechanism
- Curator reviewed · 6 references
Phenylephrine is an alpha-1 adrenergic agonist that mediates vasoconstriction and mydriasis depending on the route and location of administration. Systemic exposure to phenylephrine also leads to agonism of alpha-1 adrenergic receptors, raising systolic and diastolic pressure as well as peripheral vascular resistance. Increased blood pressure stimulates the vagus nerve, causing reflex bradycardia.
- Primary indication
- Phenylephrine is available in various drug formulations, which have different indications.Curator reviewed · 100 structured indications
- Formula / weight
- C9H13NO2 · 167.205 g/mol (avg)
- First approval
- Canada, 1996 · United States, 1958
- Code names
- J8.601K
- Brand names
Resolves to
SONNWYBIRXJNDC-VIFPVBQESA-NSMILESCNC[C@H](O)C1=CC(O)=CC=C1What you can answer from here — as of September 19, 2026
Which drugs share a target with Phenylephrine, and which of those have an active Phase 3 trial?
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